- Workshop Encefalopatia Traumática Crônica: Projeto dos Jogadores de Futebol. Dia 16/02/2016 Inrad: 1o andar anfiteatro 3 05/02/2016
- 7T papers 20/08/2015
- The 4th Latin American School for Education, Cognitive and Neural Sciences 09/10/2013
- Journal Club – September 25, 2013 26/09/2013
- CANCELADA-Aula de Segurança em Ressonância Magnética 03/10/2013 16/09/2013
Our understanding of faces reflects both our perception of their facial features and our social knowledge. This interaction of stereotypes and vision can be observed in brain signals in fusiform gyrus and orbitofrontal cortex.
The brain cancer glioblastoma relies on aberrant epidermal growth factor receptor (EGFRvIII) signaling for tumorigenesis. An essential co-receptor and feed-forward circuit maintain signaling in this deadly disease.
In high-throughput electron microscopy, a simple method to reduce artifacts helps reveal the architecture of circuits in the developing zebrafish olfactory bulb.
Researchers show that orbitofrontal neurons perform the same value-related computations across different decisions. Value computations are therefore a critical feature around which orbitofrontal representations are organized.
Pericytes are vascular mural cells embedded in the basement membrane of brain microvessels that, in the CNS, are uniquely positioned in the neurovascular unit between endothelial cells, astrocytes and neurons. Here the authors examine the key signaling pathways between pericytes and their neighboring cells regulating CNS functions in health and disease.
The authors document a novel neurogenic mechanism to explain the clinical syndrome known as spinal cord injury–induced immune deficiency. Specifically, they show that new spinal–splenic sympathetic circuitry forms below the level of injury, creating an exaggerated sympathetic anti-inflammatory reflex. Inhibiting excitatory interneurons within this circuitry blocks immune suppression.
In this study the authors have imaged the growth of adult-born dentate granule cell dendrites in vivo longitudinally over several weeks. They have found that branch addition is dependent on behavioral experience and molecular cues and that pruning acts homeostatically to promote a similar dendritic structure for all granule cells.
Theories propose hippocampal memories are consolidated to the cortex during reactivation events known as replay. However, the involvement of the medial entorhinal cortex (MEC) in consolidation remains poorly understood. Ólafsdóttir et al. demonstrate coordinated replay between the hippocampus and MEC, with hippocampus leading, suggesting hippocampal memories are broadcast to MEC.
By combining neuroimaging with an implicit behavioral measure (mouse-tracking), the authors demonstrate that stereotypes can alter the brain's visual representation of a face's gender, race, and emotion. Perceptions of social categories were biased by a subject's stereotypical associations, and this bias correlated with neural representations of those categories.
Glioblastoma is a deadly brain tumor with no cure. The cytokine receptor OSMR is identified as a new key player in glioblastoma pathogenesis. OSMR orchestrates a feed-forward mechanism with the oncogenic protein EGFRvIII and the transcription factor STAT3 to drive oncogenesis. Loss of OSMR impairs EGFRvIII-STAT3 signaling and glioblastoma tumorigenesis.